Is Nontargeted Screening Reproducible?
نویسندگان
چکیده
منابع مشابه
Is the aldosterone:renin ratio truly reproducible?
Letters to the Editor will be published, if suitable, as space permits. They should not exceed 1000 words (typed double-spaced) in length and may be subject to editing or abridgment. Rossi et al recently concluded that the aldosterone:renin ratio (ARR) is reproducible. 1 However, we think that several common errors were performed in their data interpretation, as described below. In the Bland-Al...
متن کاملIs My Network Module Preserved and Reproducible?
In many applications, one is interested in determining which of the properties of a network module change across conditions. For example, to validate the existence of a module, it is desirable to show that it is reproducible (or preserved) in an independent test network. Here we study several types of network preservation statistics that do not require a module assignment in the test network. W...
متن کاملDevelopment of an HTS assay for EPHX2 phosphatase activity and screening of nontargeted libraries.
The EPXH2 gene encodes soluble epoxide hydrolase (sEH), which has two distinct enzyme activities: epoxide hydrolase (Cterm-EH) and phosphatase (Nterm-phos). The Cterm-EH is involved in the metabolism of arachidonic acid epoxides that play important roles in blood pressure, cell growth, inflammation, and pain. While recent findings suggested complementary biological roles for Nterm-phos, researc...
متن کاملWhy is random close packing reproducible?
We link the thermodynamics of colloidal suspensions to the statistics of regular and random packings. Random close packing has defied a rigorous definition yet, in three dimensions, there is near universal agreement on the volume fraction at which it occurs. We conjecture that the common value of phi{rcp} approximately 0.64 arises from a divergence in the rate at which accessible states disappe...
متن کاملNovel or reproducible: That is the question.
When did novelty become a criterion for stellar science that is rewarded with promotions, funding and tenure? Many so-called highimpact journals require novelty in the papers they publish (e.g. “The criteria for a paper to be sent for peer-review are that the results seem novel, arresting (illuminating, unexpected or surprising). . .” (Getting Published inNature: The Editorial Process,Nature; h...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Environmental Science & Technology
سال: 2018
ISSN: 0013-936X,1520-5851
DOI: 10.1021/acs.est.8b05671